Amorolfine drug intermediates p-tert-amyl benzyl bromide synthesis method

摘要

#$%^&*AU2016102296A420170223.pdf#####ABSTRACT Amorolfine drug intermediates p-tert-amyl benzyl bromide synthesis method, comprising the following steps: a reaction vessel was added 0.71mol tert-amyl benzylamine (2), 0.82-0.84mol bromoethane, 0.86 mol cuprous bromide, 300ml oxalic acid solution, the solution temperature is raised to 80-85 C, the stirring speed was controlled at 130-170rpm, reacted for 17-19h, the temperature of the solution is reduced to 10-15'C, 600ml sodium bromide solution was added, extracted with cyclohexane 7-9 times, and the extract successively washed with saline solution, potassium hydrogen sulfite solution, dehydrated with dehydrating agent, vacuum distillation, collecting fractions of 110--115 C, recrystallized in the nitromethane, ultimately got p-tert-amyl benzyl bromide (1) crystals.