首页>
外国专利>
Clofibrate drug intermediates chlorophenoxy isobutyrate synthesis method
Clofibrate drug intermediates chlorophenoxy isobutyrate synthesis method
展开▼
机译:氯贝特药物中间体氯丁氧基异丁酸酯的合成方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
#$%^&*AU2016102312A420170223.pdf#####ABSTRACT Clofibrate drug intermediates chlorophenoxy isobutyrate synthesis method, comprising the following steps: equipped with a stirrer, a thermometer, reflux condenser, a dropping funnel, the reaction vessel was added 0.62mol chlorophenoxy amine solution(2), 300ml hexane solution, 500ml sodium sulfite solution, 0.71-0.73mol acetamide solution(3), controlling the stirring speed at 130-160rpm, the solution temperature was raised to 60-650 C, 0.75-0.79mol 1-bromo-diamine solution(4), after the addition, maintaining the reflux for 90-130min, adding oxalic acid solution, the pH was adjusted to 4-5, the temperature of the solution is reduced to 3-7 C, the precipitated solid was filtered, washed with salt solution, washed with propionitrile solution, washed with ethylenediamine solution, dehydrated with dehydrating agent, recrystallized from nitromethane solution, got crystals of chlorophenoxy isobutyrate.
展开▼