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MARKERS FOR ACUTE MYELOID LEUKEMIAS WITH CORE BINDING FACTOR REARRANGEMENTS AND OTHER GENETIC SUBTYPES AND USES THEREOF
MARKERS FOR ACUTE MYELOID LEUKEMIAS WITH CORE BINDING FACTOR REARRANGEMENTS AND OTHER GENETIC SUBTYPES AND USES THEREOF
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机译:具有核心结合因子重排和其他遗传亚型的急性髓样白血病的标志及其用途
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摘要
Genes exhibiting specific mutational and/or transcriptional patterns in AMLs and various AML subtypes such as CBF-AMLs, t(8;21) AMLs, inv(16) AMLs; MLL-rearranged AMLs and other subtypes relative to other types of AMLs and/or normal CD34+ cells are disclosed. The use of these mutational and/or transcriptional patterns for the classification, diagnosis and treatment of AMLs is also disclosed.
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机译:在 AML I>和各种 AML I>亚型(例如 CBF-AML,t(8; 21)AML,inv(16))中表现出特定突变和/或转录模式的基因反洗钱;公开了相对于其他类型的 AMLs I>和/或正常CD34 + Sup>细胞的MLL重排的AMLs i>和其他亚型。还公开了这些突变和/或转录方式在 AML I>的分类,诊断和治疗中的用途。
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