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COMPOSITIONS, PACKAGED PHARMACEUTICALS, AND METHODS OF USING HEDGEHOG PATHWAY MODULATORS FOR THE SENSITIZATION OF RESISTANT TUMORS
COMPOSITIONS, PACKAGED PHARMACEUTICALS, AND METHODS OF USING HEDGEHOG PATHWAY MODULATORS FOR THE SENSITIZATION OF RESISTANT TUMORS
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机译:成分,包装的药物以及使用Hedgehog通路调节剂敏化耐药性肿瘤的方法
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摘要
Compositions, packaged pharmaceuticals, and methods of treatment by the sensitization of resistant tumors are provided. The compositions comprise a combination of a hedgehog pathway modulator, such as itraconazole, and a chemotherapeutic agent. Tumor cells in mammalian subjects treated with the hedgehog pathway modulator are sensitized to the effects of the chemotherapeutic agent, thus increasing the therapeutic index of the agent and reducing toxicity to the subject.
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