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A SYSTEM AND METHOD FOR COMPENSATING NOISE IN SEQUENCE DATA FOR IMPROVED ACCURACY AND SENSITIVITY OF DNA TESTING
A SYSTEM AND METHOD FOR COMPENSATING NOISE IN SEQUENCE DATA FOR IMPROVED ACCURACY AND SENSITIVITY OF DNA TESTING
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机译:用于补偿序列数据中的噪声以提高DNA测试的准确性和灵敏度的系统和方法
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摘要
Some techniques for compensating noise in nucleotide sequencing data include smoothing data for a first reference sequence based on amounts of a subset of reference sequences. An amount of each reference sequence of the subset is multiplied by a corresponding smoothing factor for the reference sequence. The smoothing factor for the reference sequence is based on a spread of the amounts of the reference sequence in the training data. Some techniques include applying a hidden Markov model in which hidden states represent normal condition and a condition of interest at each of multiple pairs of complementary fractions of the sample exhibiting the condition. Transitions from a non-normal condition at a first fraction are confined to states at the first fraction. The normal condition at the first fraction can transition to a state of a different fraction only if the different state represents the normal condition at a complementary fraction.
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