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PREPARATION OF A DRUG FORM CONTAINING AMORPHOUS APIXABAN
PREPARATION OF A DRUG FORM CONTAINING AMORPHOUS APIXABAN
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机译:含非处方药APIXABAN的药物制剂的制备
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摘要
The invention describes a preparation method of apixaban in an amorphous form by means of the method of encapsulation in a porous carrier or of hot-melt extrusion. Apixaban prepared this way either has the form of an amorphous dispersion in a pharmaceutically acceptable polymer, or the form of a solid solution with a pharmaceutically acceptable polymer and can be used for the treatment or prevention of thromboembolic events. The invention also relates to a pharmaceutical composition containing amorphous apixaban prepared using the encapsulation in a porous carrier and the hot-melt extrusion methods.
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