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SORAFENIB HEMI-P-TOSYLATE MONOHYDRATE CRYSTAL AND PREPARATION PROCESS THEREOF
SORAFENIB HEMI-P-TOSYLATE MONOHYDRATE CRYSTAL AND PREPARATION PROCESS THEREOF
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机译:索拉非尼半-对-甲苯磺酸一水合物晶体及其制备方法
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摘要
The present invention relates to the field of medicinal technology, and in particular, to sorafenib hemi-p-tosylate monohydrate crystal and preparation process thereof. The crystal has diffraction peaks occurring at 2θ angle of about 5.62, 6.67, 8.05, 9.06, 9.63, 9.91, 10.95, 11.25, 13.48, 14.00, 14.60, 15.08, 15.75, 16.20, 16.62, 16.80, 17.23, 18.40, 18.97, 19.32, 19.82, 20.49, 20.74, 21.51, 22.56, 22.86, 23.37, 23.71, 24.20, 24.71, 24.97, 25.54, 25.80, 26.18, 27.14, 27.48, and 28.29 degree in a X-ray powder diffraction pattern, and some advantages, such as a high stability, a low hygroscopicity and the like.
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