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PREDICTIVE TEST FOR MELANOMA PATIENT BENEFIT FROM INTERLEUKIN-2 (IL2) THERAPY
PREDICTIVE TEST FOR MELANOMA PATIENT BENEFIT FROM INTERLEUKIN-2 (IL2) THERAPY
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机译:白介素2(IL2)治疗对黑色素瘤患者益处的预测试验
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摘要
A method is disclosed for predicting in advance whether a melanoma patient is likely to benefit from high dose IL2 therapy in treatment of the cancer. The method makes use of mass spectrometry data obtained from a blood-based sample of the patient and a computer configured as a classifier and making use of a reference set of mass spectral data obtained from a development set of blood-based samples from other melanoma patients. A variety of classifiers for making this prediction are disclosed, including a classifier developed from a set of blood-based samples obtained from melanoma patients treated with high dose IL2 as well as melanoma patients treated with an anti-PD-1 immunotherapy drug. The classifiers developed from anti-PD-1 and IL2 patient sample cohorts can also be used in combination to guide treatment of a melanoma patient.
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