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OBINUTUZUMAB AND RITUXIMAB VARIANTS HAVING REDUCED ADCP
OBINUTUZUMAB AND RITUXIMAB VARIANTS HAVING REDUCED ADCP
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机译:奥比妥单抗和利妥昔单抗变体的ADCP降低
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摘要
The present invention relates to modified antibodies. In particular, the present invention relates to recombinant monoclonal antibodies or fragments, including chimeric, primatized or humanized antibodies or fragments, having reduced effector function and altered ability to mediate cell signaling activity by a target antigen. In addition, the present invention relates to nucleic acid molecules encoding such antibodies, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the antibodies of the invention, and to methods of using these antibodies in treatment of disease.
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