RETROVIRAL CONSTRUCT HARBORING A LET-7 INSENSITIVE NUCLEIC ACID ENCODING HMGA2 AND METHODS OF USE THEREOF

摘要

A retroviral construct harboring nucleic acids encoding a high mobility group AT-hook 2 (HMGA2) protein and lacking let-7 binding sites is described as are methods of using the retroviral vector to increase the efficacy and in vivo expansion of transduced cells in gene therapy applications.