CORE-SHELL LUMINESCENT NANOMATERIAL AND PREPARATION METHOD THEREOF

摘要

Provided are a core-shell luminescent nanomaterial and a preparation method thereof. The core-shell luminescent nanomaterial has UCNPs as a core and an alkaline manganese compound as a shell. The UCNPs as the core can achieve a fluorescent labeling/imaging function, and the alkaline manganese compound as the shell can enable MRI imaging of a tumor cell. While a small amount of the material might enter a normal cell as a result of the recognition rate being less than 100%, the normal cell will not be detected because the low acidity inside the normal cell prevents the alkaline manganese compound from being dissolved and releasing a manganese ion, and the UCNPs of the core will not be released and so will not affect NMR imaging and fluorescent imaging. This can greatly increase the recognition rate of a tumor cell. The core-shell luminescent nanomaterial can be used in the high-sensitivity fluorescence detection and MRI imaging and analysis of a tumor cell and a tumor tissue, providing more accurate information for medical detection and treatment.