IN VIVO METHOD FOR DIFFERENTIATING HUMAN PLURIPOTENT STEM CELLS INTO ATRIAL CARDIOMYOCYTES

摘要

The present invention is in the field of pluripotent stem cells, more particularly cardiomyocytes derived from pluripotent stem cells. The present invention provides a novel method for differentiating human pluripotent stem cells into a population of cardiomyocytes having an atrial phenotype, and use of said atrial cardiomyocytes for screening of drugs, AF disease model,and others. The method of the invention is particularly useful to generate cardiomyocytes having a moredeveloped or mature atrialphenotype and/or to generate higher yield of cardiomyocytes having an atrialphenotype.