首页> 外国专利> NELUMBO NUCIFERA CALLUS EXTRACT HAVING INCREASED CONTENT OF GALLIC ACID, METHOD FOR PREPARING SAME, AND WHITENING COSMETIC COMPOSITION CONTAINING SAME

NELUMBO NUCIFERA CALLUS EXTRACT HAVING INCREASED CONTENT OF GALLIC ACID, METHOD FOR PREPARING SAME, AND WHITENING COSMETIC COMPOSITION CONTAINING SAME

机译：胆汁酸含量提高的 NELUMBO NUCIFERA 愈伤组织提取物，其制备方法和增白包含相同成分的化妆品成分

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摘要

The present invention relates to Nelumbo nucifera callus having an increased content of gallic acid or an extract thereof and to a method for preparing the same. The Nelumbo nucifera callus extract according to the present invention has an excellent whitening effect by containing a large amount of gallic acid, and thus can be advantageously used as a cosmetic composition. 展开▼

机译：本发明涉及具有增加的没食子酸含量的 Neucbo nucifera 愈伤组织或其提取物，并且涉及其制备方法。通过包含大量没食子酸，根据本发明的莲子愈伤组织提取物具有优异的增白效果，因此可以有利地用作化妆品组合物。 展开▼

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公开/公告号WO2017171423A2

专利类型

公开/公告日2017-10-05

原文格式PDF

申请/专利权人 CELLTRION INC.;BIO-FD&C CO. LTD;
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申请/专利号WO2017KR03472

发明设计人 KIM YEON SOOK;MOON SUNG HO;CHANG SHIN JAE;MOH SANG HYUN;LEE JEONG HUN;SEO HYO HYUN;MOH JI HONG;KIM SOO YUN;PARK JEONG GON;KIM JUNG YEON;KIM JAE HUN;KIM HYEONG MI;BAE JUNG SOO;KIM JUNG YUN;KIM JU YEON;LIM JOO HYUCK;LEE SEUNG KI;
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申请日2017-03-30

分类号A61K8/97;A61K8/368;A61Q19/02;

国家 WO

入库时间 2022-08-21 13:29:24

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1. 使用包含生物活性莲(NELUMBO NUCIFERA)提取物的组合物增加脂肪分解的方法 [P] . 中国专利： CN109689026A . 2019-04-26

2. 用于皮肤增白的含有天女木兰提取物作为活性成分的化妆品组合物 [P] . 中国专利： CN101686929B . 2013.03.20

3. Nelumbo nucifera callus extract having increased content of gallic acid, method for preparing same, and whitening cosmetic composition containing same [P] . US10947497B2 . 2021-03-16

机译： Nelumbo Nucifera 愈伤组织提取物具有增加的小酸含量，其制备方法以及含有相同的美白化妆品组合物

4. NELUMBO NUCIFERA CALLUS EXTRACT HAVING INCREASED CONTENT OF GALLIC ACID, METHOD FOR PREPARING SAME, AND WHITENING COSMETIC COMPOSITION CONTAINING SAME [P] . 美国专利： US2019194603A1 . 2019-06-27

机译：具有增加的五倍子酸含量的莲核愈伤组织提取物，其制备方法和增白包含相同成分的化妆品成分

5. NELUMBO NUCIFERA CALLUS EXTRACT HAVING INCREASED CONTENT OF GALLIC ACID, METHOD FOR PREPARING SAME, AND WHITENING COSMETIC COMPOSITION CONTAINING SAME [P] . 欧洲知识产权局专利： EP3437632A2 . 2019-02-06

机译：具有增加的五倍子酸含量的莲核愈伤组织提取物，其制备方法和增白包含相同成分的化妆品成分

1. Evaluation for Whitening Efcacy of Cosmetics Containning Extract from Tricholoma Matsutake Sing [J] . Wang Nan, Zhou Zhaoqing, Yin Yuexuan, 日用化学品科学(英文版) . 2017,第002期

2. Simultaneous Determination of Gallic Acid and Cinnamic Acid Content in Rhubarb by HPLC [J] . Han Qian, Wei Jiangcun, Chen Yong, 植物病虫害研究：英文版 . 2020,第003期

3. Nelumbo nucifera extracts as whitening and anti-wrinkle cosmetic agent [J] . Tagon Kim, Hee Jin Kim, Sung Ki Cho, The Korean journal of chemical engineering . 2011,第2期

4. Rapid Validated HPTLC Method for Estimation of Betulinic acid in Nelumbo nucifera (Nymphaeaceae) Rhizome Extract [J] . Phytochemical Analysis . 2010,第6期

5. Polyphenols extract from lotus seedpod ( Nelumbo nucifera Gaertn.): Phenolic compositions, antioxidant, and antiproliferative activities [J] . Yingbin Shen, Yifu Guan, Xun Song, Food Science & Nutrition . 2019,第9期

6. Development of Antimicrobial Nanoemulsions Containing Nelumbo nucifera Extract [C] . SIRIKARN Pengon, NAWINDA Chinatangkul, CHUTIMA Limmatvapirat International conference and exhibition on Pharmaceutical Sciences and Technology . 2020

7. The seasonal changes in the lipophilic extractives content and composition of black spruce (Picea mariana), balsam fir (Abies balsamea), and their associated TMP-mill samples. [D] . Grimmett, Mark G. 2002

8. Polyphenols extract from lotus seedpod (Nelumbo nucifera Gaertn.): Phenolic compositions antioxidant and antiproliferative activities [O] . Yingbin Shen, Yifu Guan, Xun Song, 2019

9. Comparison of Biological Activity between Nelumbo nucifera G. Extracts and Cosmetics Adding Nelumbo nucifera G. [O] . Jin-young Lee, Mi-ra Yu, Bong-jeun An 2010

1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

2. Simultaneous determination of gallic acid and p-coumaric acid in rat plasma by UPLC-MS/MS and its application to a comparative pharmacokinetic study after oral administration of monomer compound and red wine extract [J] . Huijie Lv ,Mengyu Zou ,Weichao Yu . 多酚杂志 . 2019,第1期

3. Effect of Salinity Stress on Capsicum annuum Callus Growth, Regeneration and Callus Content of Capsaicin, Phenylalanine, Proline and Ascorbic Acid [J] . Zahra N. A1 Hattab1 ,Saadon A. Al-Ajeel2 ,Ekhlas A. E1 Kaaby1 . 生命科学（ISSN1934-7391） . 2015,第007期

4. GC/MS对罗汉果提取物挥发性成分的分析及其对提高卷烟吸食品质的作用 [C] . 刘绍华 ,黄泰松 ,邹克兴 . 广西烟草学会2008年度学术年会 . 2009