APPLICATION OF TETRAMETHYLPYRAZINE DERIVATIVE TETRAMETHYLPYRAZINE NITRONE IN PREVENTION AND TREATMENT OF BRAIN INJURY DISEASES

摘要

The present invention belongs to the technical field of drugs, and relates in particular to an application of a tetramethylpyrazine derivative tetramethylpyrazine nitrone in the preparation of a drug and the prevention and treatment of brain injury diseases. Experiments show that tetramethylpyrazine nitrone can improve traumatic brain injuries and brain injuries after subarachnoid haemorrhages. Specifically, tetramethylpyrazine nitrone can improve the behaviour of model rats having traumatic brain injuries and subarachnoid haemorrhages, reduces the cerebral infarction area of a traumatic brain injury, improves the vasospasm state after a subarachnoid haemorrhage, and thus has a protective effect on brain tissue. The mechanism of action of tetramethylpyrazine nitrone is related to inhibiting oxidative stress injury, inhibiting inflammation and resisting apoptosis. Tetramethylpyrazine nitrone may be used as a drug which prevents or treats brain injury diseases, particularly traumatic brain injuries and subarachnoid haemorrhages, and may be made into a variety of dosage forms with a medicinal carrier.