B CD23 -IgE HUMANIZED ANTI-IgE ANTIBODIES THAT CROSSLINK CD23 ON B LYMPHOCYTES BUT DO NOT SENSITIZE MAST CELLS

摘要

Newly humanized anti-IgE antibodies are described. The antibody can bind free IgE, membrane bound IgE on B lymphocytes, IgE bound by CD23, but not IgE bound by high affinity IgE. Fc receptors on mast cells. The present invention also provides a method of treating or preventing allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic sinusitis, systemic mastocytosis, Mediated diseases including gastrointestinal tract aspergillosis, recurrent idiopathic angioedema, and eosinophil-related gastrointestinal tract diseases.