TISSUE ANTI-ADHESION AGENT COMPRISING POLY(GAMMA-GLUTAMIC ACID) AND PREPARATION METHOD THEREOF

摘要

In the present invention, poly(gamma-glutamic acid), which is a hydrophilic polymer, is simply mixed with a hydrogel-forming hyaluronic acid, or a temperature-sensitive polymer, Pluronic, to form a hydrogel which is more stable in aqueous solutions than conventional hydrogels. Since the hydrogel of the present invention forms a gel due to the physicochemical properties of the polymer without a chemical cross linking reaction, the preparation of the hydrogel is very simple and the prepared hydrogel is easy to use in living organisms. The stability of the hydrogel can be controlled by controlling the molecular weight and concentration of the poly(gamma-glutamic acid) included in the hydrogel. Unlike conventional hydrogels free of poly(gamma-glutamic acid), which makes tissue adhesion readily occur, the hydrogel containing poly(gamma-glutamic acid) according to the present invention shows tissue anti-adhesion effects and therefore, is effective as a tissue anti-adhesion agent.;COPYRIGHT KIPO 2016