Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis vulnerable plaque AAA and stroke

摘要

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate the reaction of biological organisms upon introduction of the medical device into the organism. Medical devices can be coated with a number of biocompatible materials. The therapeutic agent, preparation or compound may be admixed with the biocompatible material and attached to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce the response of the biological organism upon introduction of the medical device into the organism. In addition, these therapeutic agents, agents and / or compounds may be used to promote healing, including prevention of thrombosis. Agents, agents and / or compounds may also be used to treat certain diseases, including vulnerable plaques. The therapeutic agent may also be delivered to the area of the disease site. In topical delivery, liquid formulations may be desirable to increase the efficacy and delivery of particular medicaments. In addition, the device can be modified to promote endothelial cell proliferation. Can be used to hold the agent or compound on the medical device until various materials and coating methods are delivered and placed. In addition, the device used to deliver the implantable medical device may be modified to reduce the potential for damage of the implantable medical device during deployment. Medical devices include stents, grafts, connecting devices, perivascular wraps, seams and staples. In addition, various polymer mixtures may be used to control the rate of elution of therapeutic agents, agents and / or compounds from the implantable medical device.;Restenosis, vulnerable plaque, stroke, pro-bacol, sirolimus, local vascular delivery