Diketoreductase DOUBLE-CARBONYL REDUCTASE MUTANT AND APPLICATION OF SAME

摘要

The present invention relates to a method for producing a 3R, 5S-dicarbonyl group compound, a 3R, 5S-dicarbonyl group compound obtained by providing a Diketoreductase mutant, a nucleotide acid coding sequence, an expression cassette containing the above sequence, a recombinant vector, The value is greater than 99% and the de value is about 90%. The Diketoreductase mutants are key drug intermediates and, in particular, catalyze efficient synthesis of chiral dicarbonylhexanoic acid chains of statins.