- METHODS FOR TREATING PULMONARY NON-TUBERCULOUS MYCOBACTERIAL INFECTIONS

摘要

Methods for treating a pulmonary infection, such as a non-tuberculous mycobacterial lung infection, for at least one treatment cycle in a patient in need of treatment are provided herein. The method comprises administering to a patient ' s lung a pharmaceutical composition comprising a liposome complexed aminoglycoside comprising a lipid component comprising an electrically neutral lipid and an aminoglycoside. Administration comprises aerosolizing a pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycosides and liposomally complexed aminoglycosides and administering the aerosolized pharmaceutical composition to a patient''s lung / RTI The methods provided herein result in a change from the baseline for semi-quantitative measures for mycobacterial cultures in the treated patients, and / or a NTM culture conversion to negative during or after the administration period.