Xa HYDRAZINE COMPOUND AS BLOOD COAGULATION FACTOR XA INHIBITOR

摘要

The present invention relates to a compound having the structure of the formula (I), or a pharmaceutically acceptable salt thereof, (I) Wherein X is selected from a 3-9 membered carbocyclic ring or a benzo ring thereof, a 4-10 membered heterocyclic ring or a benzo ring thereof; Y and Z are each independently selected from a 4-9 membered saturated heterocyclic ring; R _1-3 are each independently H, F, Cl, Br, I, CN, OH, SH, NH _2, CHO, COOH, or selected from or optionally substituted by R ₀₁ C _1-10 alkyl or heteroaryl alkyl, C _3-10 cycloalkyl hydrocarbyl or heterocyclo hydrocarbyl, C _3-10 cycloalkyl is selected from hydrocarbyl or a C _1-10 alkyl or heterocyclic alkyl substituted by heterocycloalkyl hydrocarbyl. The compounds of the present invention can be used for the treatment and prevention of thromboembolic disorders as anticoagulants and the present invention can satisfy the actual demand for selective inhibitors of blood coagulation factor Xa by providing potent inhibitors of blood coagulation factor Xa.