CHK1 ATR METHOD FOR TREATING CANCER USING A COMBINATION OF CHK1 AND ATR INHIBITORS

摘要

The present invention relates to a method of treating cancer in a patient by administering a compound useful as an inhibitor of an ATR protein kinase in combination with a compound useful as an inhibitor of Chk1 protein kinase. The above-mentioned combination shows a remarkable synergistic effect in treating cancer, even though the targeted protein kinase is in the same biological pathway. Furthermore, the present invention also provides a method of treating a subject suffering from a disease or condition selected from the group consisting of: administering a compound useful as an inhibitor of ATR protein kinase to a patient; Administering a compound useful as an inhibitor of Chk1 protein kinase; As well as a method of treating cancer by administering a DNA damaging agent. The compounds used in the present invention are represented by Formulas I and II: Formula I (II) In the above equations, Wherein the variables are as defined herein.