CAR- NK-92 CAR-EXPRESSING NK-92 CELLS AS CELL THERAPEUTIC AGENTS

摘要

The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably containing two vector integrated loci in the cell genome. The invention further relates to the use of such ErbB2-specific NK-92 cells or cell lines in the prophylaxis and / or treatment of cancer, preferably ErbB2-expressing cancer. In addition, the present invention relates to the use of such ErbB2-specific NK-92 cells or cell lines for targeted cell therapy and / or for adoptive cancer immunotherapy. Further, the present invention relates to a method for producing an ErbB2-specific NK-92 cell or cell line, as well as a method for identifying an ErbB2-specific NK-92 cell or cell line, and an ErbB2- NK-92 cells or cell lines, as well as their uses.