CXCR2 Method for Inducing Ectodermal Differentiation of Embryoid Bodies Derived from Human Pluripotent Stem Cells by CXCR2 Stimulation

摘要

The present invention relates to a method for differentiating human pluripotent stem cell-derived embryoid body into ectoderm through stimulation of chemokine (C-X-C motif) receptor 2 (CXCR2). More specifically, the present invention relates to a method for stimulating differentiation into ectoderm, by activating CXCR2 which is a surface receptor of human pluripotent stem cell-derived embryoid body after stimulating the same with CXCR2-specific ligand GRO-. According to the present invention, method for differentiating human pluripotent stem cell-derived embryoid body into ectoderm through stimulation of CXCR2 enables the promotion of differentiation into a specific germinal cells which are origin of target cells, as is a first crucial step for inducing differentiation into specific cells, thereby increasing applicability and efficiency of stem cells as an agent for cell therapies.