METHOD FOR PREPARING BENZOFURAN COMPOUNDS INCLUDING GRAMNIPHENOL F, GRAMNIPHENOL G, CICERFURAN, MORUNIGROL C AND DERIVATIVES THEREOF

摘要

The present invention relates to a method for preparing natural benzofurans including gramniphenol F, gramniphenol G, morunigrol C and 3′,5′-di-O-methyl analogues thereof and cicerfuran by using 2,4-dihydroxybenzaldehyde, 5-bromoresorcinol and sesamol. In the method according to the present invention, region-selective prenylation, Ramirez gem-dibromo olefination, Miyaura borylation and Suzuki coupling are used. In addition, the compounds were determined for anti-inflammatory effects through a test for production of nitrogen oxide in liposaccharide-induced RAW-264.7 macrophages. All of the compounds show weak to medium (16-42%) inhibitory activities, are not toxic and have an IC_50 value of 9.1 to 25.2 μM.;COPYRIGHT KIPO 2017