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METHOD FOR SELECTING NEUROTOXINS USING NEURAL CELLS EXPRESSING POLYSIALYLATED NEURONAL CELL ADHESION MOLECULE (PSA-NCAM)
METHOD FOR SELECTING NEUROTOXINS USING NEURAL CELLS EXPRESSING POLYSIALYLATED NEURONAL CELL ADHESION MOLECULE (PSA-NCAM)
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机译：利用表达聚唾液酸化神经细胞粘附分子（PSA-NCAM）的神经细胞选择神经毒素的方法
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摘要
The present invention relates to a method for selecting neurotoxins using neural cells which express polysialylated neuronal cell adhesion molecule (PSA-NCAM). When neural cells differentiated from human embryonic stem cell-derived PSA-NCAM-positive human neural progenitor cell (hNPC^(PSA-NCAM+)) are treated with a neurotoxic substance, cell viability decreases, cytotoxicity is induced, and the growth of neurites is suppressed as well. Accordingly, PSA-NCAM-positive neural cells can be useful in the selection of neurotoxins in vitro.;COPYRIGHT KIPO 2017
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