PEG PROCESS FOR THE CONJUGATION OF A PEPTIDE OR PROTEIN WITH A REAGENT COMPRISING A LEAVING GROUP INCLUDING A PORTION OF PEG

摘要

The present invention relates to a new conjugate (joined) to form a reagent capable of reacting with at least one nucleophile present in the peptide or protein, and comprising a least one exit that is lost during the reaction with the nucleophile, in which the leaving group ( CH ₂ CH ₂ O) _n - and comprises a portion (where n is a number greater than or equal to 6), and the present invention relates to a novel production method of the conjugate containing the peptide or protein produced using the above reagent.