T T- SURVIVIN SPECIFIC T-CELL RECEPTOR TARGETING TUMOR BUT NOT T CELLS

摘要

Embodiments of the present disclosure relate to engineered T cell receptors that are specific for a survivin tumor antigen but do not have "on-target off tumor" toxicity. In a particular embodiment, certain alpha and beta chains have effective anti-tumor activity, but are used in engineered T cell receptors for cell therapy that do not have a prathicidal effect. Methods, compositions and kits are provided herein.