GST-PI RNA RNA INTERFERENCE AGENTS FOR GST-PI GENE MODULATION

摘要

The present invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. RNA interference molecules can be used in methods of preventing or treating diseases such as malignant tumors. A variety of modified or chemically-modified siRNA structures are provided for one or more of the nucleotides. Advantageous structures include 2'-deoxynucleotides located in the seed region, as well as siRNAs with other nucleotide modifications.