New compounds or pharmaceutically acceptable salt thereof selective for amyloid- plaque and method for imaging amyloid- plaque in vivo using the same

摘要

The present invention relates to a novel compound which is selective for beta amyloid plaques or a pharmaceutically acceptable salt thereof and a method for imaging beta amyloid plaques using the same, more specifically, And a method for synthesizing a novel compound or a pharmaceutically acceptable salt thereof, which can be used therefor, in a high-resolution three-dimensional imaging through a low-energy-source two-photon microscope. A novel compound, or a pharmaceutically acceptable salt thereof, selective to beta amyloid plaques according to the present invention releases strong two-photon fluorescence and is selectively stained with amyloid. In addition, the compound or its pharmaceutically acceptable salt has a property of passing through the blood brain barrier of a rat efficiently because of its low molecular weight and electrically neutral nature. Based on these properties, amyloid deposition in the brain of transgenic mice can be imaged into a high-resolution three-dimensional image using a two-photon microscope.