Ninjurin-1 Composition for the prevention and treatment of an inflammatory brain disease comprising a adhesion motif of Ninjurin-1 protein as an active ingradient

摘要

The present invention relates to a composition for preventing and treating brain injury comprising an adhesion motif of Ninjurin-1 (nerve injury-induced protein-1) protein as an active ingredient. More specifically, the present invention relates to a composition for preventing and treating brain injury, ) And asparagine 37, reduce the cerebral ischemic volume of the postischemic brain in the middle cerebral artery occlusion (MCAO) rat model, and impair motor function and neurological loss And inhibits the neuronal inflammatory reaction by inhibiting the activity of microglial cells and neutrophils, so that it can be effectively used as an active ingredient of a composition for preventing and treating brain injury.