6S-5- CRYSTAL FORM OF 6S-5-METHYLTETRAHYDROFOLATE SALT AND METHOD FOR PREPARING SAME

摘要

The present invention relates to a crystal form of (6S) -5-methyltetrahydrofolate salt and a method of preparing the same, wherein the crystalline form is a crystalline form of calcium salt of C-type (6S) -5- The diffraction spectrum shows diffraction peaks at 2θ angles of 6.3 ± 0.2 and 19.2 ± 0.2 or crystalline form of (6S) -5-methyltetrahydrofolic acid strontium salt, the X-ray diffraction spectrum of which has 2θ angles of 6.5 ± 0.2 and 22.0 ± 0.2 where there is a diffraction peak. The crystalline form of (6S) -5-methyltetrahydrofolate according to the present invention has excellent physical and chemical properties, and is stable. The purity is high. Excellent reproducibility and is more suitable for large-scale industrial production.