Dab2 Composition for prevention or treatment of autoimmune disease comprising Dab2-overexpressing dendritic cells

摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of autoimmune diseases, and more particularly to a pharmaceutical composition for preventing or treating autoimmune diseases comprising semi-mature dendritic cells overexpressing the Dab2 gene.The composition according to the present invention is characterized in that the semi-mature dendritic cells having Dab2 gene overexpression or Dab2 protein activity as an active ingredient and the Dab2 gene overexpressing or Dab2 protein having increased activity are antigen-specific Inhibiting T cell proliferation, inhibiting the expression of inflammatory cytokines, and increasing the ratio of anti-inflammatory cytokine expression and regulatory T cells, thereby preventing, ameliorating or treating autoimmune diseases including arthritis It is expected that it can be usefully used as a pharmaceutical composition for