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Resorbable scaffolds for bone repair and long bone tissue engineering

机译:可吸收支架,用于骨骼修复和长骨组织工程

摘要

A biosorbable framework for bone engineering is described, such as bone defects, especially restoration of long bone defects or increased bone length. The skeleton is porous and includes multiple side channels. In one embodiment, the backbone comprises a layer of micro-filament mesh comprising a polycaprolactam (PCL) or PCL-composite and having a pattern of 60/160 of continuous stacking and increasing 0/60/120 degrees of rotation , To form the interconnected pores. The skeleton may include a central channel filled, packed or implanted with a suitable material, such as a bioactive agent. Furthermore, the skeleton is robust but resistant to fracture and has sufficient bending, compression and torsional strength suitable for bone engineering. The slow degradation of the skeleton is sufficient for the 3D cell epilepsy to maintain structural fusion and mechanical properties during the remodeling process.
机译:描述了用于骨工程的生物可吸收框架,例如骨缺损,特别是长骨缺损的修复或增加的骨长。骨架是多孔的,并包括多个侧通道。在一个实施例中,主干包括微丝网层,该微丝网层包含聚己内酰胺(PCL)或PCL复合材料,并具有60/160的连续堆叠图案并增加0/60/120的旋转度,以形成相互连接的毛孔。骨架可以包括中央通道,该中央通道填充,填充或植入了合适的材料,例如生物活性剂。此外,骨架坚固但抗断裂,并具有足够的弯曲,压缩和抗扭强度,适用于骨骼工程。骨架的缓慢降解足以使3D细胞癫痫症在重塑过程中保持结构融合和机械性能。

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