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COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE

机译：通过抑制极光激酶来抑制有丝分裂进行的化合物和方法

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摘要

The present invention relates to a compound for treating cancer represented by the following formula (A), and a method thereof. Specifically, the present invention provides compounds that inhibit aurora kinase, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat cancer.(A)

机译：本发明涉及一种由下式（A）表示的用于治疗癌症的化合物及其方法。具体而言，本发明提供了抑制极光激酶的化合物，包含该化合物的药物组合物以及使用该化合物治疗癌症的方法。（A） 展开▼

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公开/公告号KR101748290B1

专利类型

公开/公告日2017-06-16

原文格式PDF

申请/专利权人 밀레니엄 파머슈티컬스 인코퍼레이티드;
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申请/专利号KR20137013571

发明设计人 클라이본 크리스토퍼 에프.;페이니 일로이드 제이.;보이스 리차드 제이.;셀스 토드 비.;스트로우드 스테판 지.;트라버스 스튜어트;보스 트리샤 제이.;웨더헤드 가브리엘 에스.;
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申请日2005-05-12

分类号C07D487/04;A61K31/55;A61P35;C07D487/14;

国家 KR

入库时间 2022-08-21 13:25:22

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1. 通过抑制极光激酶抑制有丝分裂的化合物和方法 [P] . 中国专利： CN104193750B . 2018.04.27

2. 通过抑制极光激酶抑制有丝分裂的化合物和方法 [P] . 中国专利： CN101014603B . 2014.08.20

3. COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE [P] . RS50568B8 . 2019-08-30

机译：通过抑制极光激酶来抑制有丝分裂进行的化合物和方法

4. COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE [P] . RS50568B9 . 2019-06-28

机译：通过抑制极光激酶来抑制有丝分裂进行的化合物和方法

5. COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION BY INHIBITION OF AURORA KINASE [P] . 韩国专利： KR101792651B1 . 2017-11-20

机译：通过抑制极光激酶来抑制有丝分裂进行的化合物和方法

1. An Aurora kinase inhibitor, AMG900, inhibits glioblastoma cell proliferation by disrupting mitotic progression [J] . Jaewook Ryu, Jaehyuk Pyo, Chang‐Woo Lee, Cancer Medicine . 2018,第11期

2. The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. [J] . Jetton N, Rothberg KG, Hubbard JG, Molecular Microbiology . 2009,第2期

3. Aurora-C kinase supports mitotic progression in the absence of Aurora-B. [J] . Slattery SD, Mancini MA, Brinkley BR, Cell cycle . 2009,第18期

4. Assessing non-mitotic pathways of an Aurora kinase inhibitor using chemical labeling and label-free MS approaches [C] . Matthew J. McKay, Judith Nicholson, Mark P. Molloy American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

5. Identification and analysis of novel mitotic inhibitors of the Caenorhabditis elegans Aurora B kinase [D] . Heallen, Todd Ryan 2008

6. An Aurora kinase inhibitor AMG900 inhibits glioblastoma cell proliferation by disrupting mitotic progression [O] . Jaewook Ryu, Jaehyuk Pyo, Chang‐Woo Lee, 2018

7. An Aurora kinase inhibitor, AMG900, inhibits glioblastoma cell proliferation by disrupting mitotic progression [O] . Jaewook Ryu, Jaehyuk Pyo, Chang-Woo Lee, 2018

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2. Transcriptional regulation of human polo-like kinases and early mitotic inhibitors [J] . Moe Tategu ,Hiroki Nakagawa ,Kaori Sasaki . 遗传学报：英文版 . 2008,第4期

3. Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells iin Vitro/i [J] . Keijiro Shiomitsu ,Xueqing Xia ,Kyle Waite . 兽医学（英文） . 2013,第1期

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5. Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line [J] . Xiao Xia Wang ,Rong Liu ,Shun Qian Jin . 细胞研究：英文版 . 2006,第4期

6. MALDI-TOF MS快速筛选蛋白激酶抑制剂的方法初探 [C] . 吕爽 ,罗群 ,林柏 . 2009年中国有机质谱年会 . 2009

7. 新型极光激酶抑制剂类抗肿瘤化合物的开发与合成工艺研究 [A] . 吴迪 . 2017