3-4--1--1H- MELK Novel 3-4-piperazin-1-ylbenzamido-1H-pyrazolopyridine derivatives or pharmaceutically acceptable salts thereof preparation method thereof and pharmaceutical composition for use in preventing or treating MELKmaternal embryonic leucine zipper kinase activity related diseases containing the same as an active ingredient

摘要

The present invention relates to a 3-(4-(piperazin-1-yl)benzamido)-1H-pyrazolopyridine derivative or pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating maternal embryonic leucine zipper kinase (MELK)-related diseases containing the same as an active ingredient. The 3-(4-(piperazin-1-yl)benzamido)-1H-pyrazolopyridine derivative according to the present invention has an excellent effect on inhibiting the expression of MELK, and can be usefully utilized for preventing or treating MELK-related diseases including types of cancer such as breast cancer, lung cancer, bladder cancer, lymphoma, polymorphism glioblastoma, cervical cancer, etc.;COPYRIGHT KIPO 2017