Polysaccharidic nanogel for protein drug delivery and preparation method thereof

摘要

The present invention relates to a polysaccharide nanogel for protein drug delivery and a preparation method thereof, and more particularly to a biocompatible polymer and a protein drug which are grafted with 3-diethylaminopropyl (DEAP) To a polysaccharide nanogel for protein drug delivery. The polysaccharide nanogel for protein drug delivery according to the present invention can be biodegradable and biocompatible in vivo by synthesizing a biocompatible polymer and a hydrophobic substance. By using the property of being weakly acidified and positively ionized, And when the pH is changed to physiological pH, the efficiency of encapsulating the protein drug in the drug delivery system can be enhanced by using the hydrophobic property of the synthetic material, and the effect of effectively introducing the nanoparticles into the cell is achieved .