APC T Method for Ex-vivo Expansion of Regulatory T cells Using Autologous Antigen-Presenting Cell and Uses Thereof

摘要

The present invention relates to a method of in vitro propagation of regulatory T cells using autologous APCs and their use,⁺Treg and CD4^-Preparing PBMCs respectively; And (b)⁺Tregs were incubated with the CD4^-PBMC, anti-CD3 antibody, anti-CD28 antibody, IL2 (interleukin2) and TGF-b (beta)⁺Proliferating CD4 RTI ID = 0.0 ⁺A method for inhibiting organ transplant rejection, and a pharmaceutical composition for preventing or treating an autoimmune disease or an inflammatory disease. Since the method of the present invention mass-regulates regulatory T cells and the amplified regulatory T cells exhibit an excellent immunosuppressive effect, it is possible to overcome various immune rejection reactions occurring in the recipient during transplantation of the same or different organs Can be effectively used.;