SLCO2B1 Novel SLCO2B1 Single Nucleotide Polymorphism Markers and Uses Thereof

摘要

The invention SLCO2B1 (Solute carrier organic anion transporter family member 2B1) the novel single nucleotide polymorphism present in the gene (single nucleotide polymorphism; SNP) and relates to the marker uses for its drug response prediction, and more particularly, SLCO2B1 polymorphism using drug response prediction or diagnostic composition, drug response prediction or diagnosis kit, method of providing information for drug selection decision, a method provides information for a single nucleotide polymorphism of a gene mutant genotype detection method and SLCO2B1 genes associated with drug response to will be. SLCO2B1 novel single nucleotide polymorphism marker presented in this invention may be useful as a biological marker associated with at least a drug transporter function. In other words, it is possible to use the novel SLCO2B1 polymorphism of the invention in a biological marker to predict or diagnose a symptom caused by differences of the sample and a drug transporter deficient individual drug transporter activity. In particular, SLCO2B1 genetic polymorphism of the present invention may contribute to the development of genetic diagnostics for Koreans by providing critical information in the development of Korean-based personalized drug therapies as a novel mutant gene discovery targeting Koreans.;