method for preparing porous PCL microsphere scaffolds as a cell delivery system

摘要

The present invention relates to a method for producing a biodegradable polymer solution containing a biodegradable polymer, a room temperature ionic liquid porogen and a sublimable solid porogen at the same time in an organic solvent to simultaneously contain an ionic liquid porogen at room temperature and a sublimable solid porogen Level 1; A second step of preparing a gel by evaporating an organic solvent from the biodegradable polymer solution; And a third step of extracting a room temperature ionic liquid porogen from the gel using a protonic solvent, and a porous microsphere produced by the method. According to the present invention, porous microspheres having controlled diameters and pore sizes can be prepared by controlling the ratio of room temperature ionic liquid porogen to sublimable solid porogen. The porous microspheres prepared according to the present invention can be applied to a cell delivery system for nerve regeneration therapy.;