High-Speed and Multi-Analysis Test Platform for Cardiotoxic Effect of Drug

摘要

The present invention relates to a device for inspecting a polymer structure integrated with sensors capable of precisely measuring the contractile force of cardiac muscle cells in real time and a method of manufacturing the same. More particularly, the present invention relates to a device for inspecting a polymer structure inspecting apparatus using a diaphragm composed of polydimethylsiloxane , The displacement of the diaphragm deformed by the contraction force of the cultured cardiac muscle cells is measured by using a laser displacement meter, and the contractile force of the cardiac muscle cell is measured through the resistance change caused by the stress of the diaphragm using the integrated sensor To an apparatus for inspecting a polymer structure and a method of manufacturing the same.The apparatus for inspecting a polymer structure according to the present invention is characterized in that a strain sensor and a reflector for measuring a laser displacement meter are integrated on a diaphragm in which the contracting force of cardiac muscle cells acts and the contracting force of the cell is measured by two different methods, This shows a possible effect.In addition, the diaphragm of the apparatus for inspecting a polymer structure according to the present invention has four sides as a fixed end, which reduces the initial bending due to the stress generated on the surface during cell growth, and thus is easy to use a laser displacement meter, It is possible to obtain a mean value according to the application, to perform a multi-drug test according to the use of a parallel well plate, and to perform a high-speed drug test according to the stage driving when measuring a laser displacement meter.;