Methods for screening Prehypertension or Hypertension Using Palmitic amide Lysophosphatidylcholines or Dihydrobiopterin

摘要

The present invention relates to a pharmaceutical composition comprising palmitic amide, lysophosphatidylcholine, dihydrobiopterin and Lp-PLA₂A method for screening a therapeutic or prophylactic agent for preventing or ameliorating hypertension or hypertension using the activity, a method for providing information necessary for diagnosis or prognosis of a hypertension or hypertension, and a diagnostic kit. According to the present invention, the plasma levels of palmitic amide, lysophosphatidylcholine and Lp-PLA₂As the level of activity decreases and the level of dihydrobiopterin increases, the plasma metabolism and Lp-PLA₂Activity changes can be used to prevent, ameliorate or screen for all hypertension or hypertension. In addition, increased blood pressure and levels of palmitic amide, lysophosphatidylcholine and Lp-PLA₂Activity has a positive correlation and has a negative correlation with the level of dihydrobiopterin, the level of the plasma metabolism or the level of Lp-PLA₂Activity can be usefully used for diagnosis of pre-hypertension or hypertension.;