首页> 外国专利> -/ T USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS FOR ANTI-LEUKEMIA/LYMPHOMA TREATMENT

-/ T USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS FOR ANTI-LEUKEMIA/LYMPHOMA TREATMENT

机译:-/ T第三方抗中枢性T细胞用于抗白血病/淋巴瘤的治疗

摘要

The present invention provides a method for treating a disease in a subject in need thereof. The method comprises: (a) implanting a non-common gene cell or tissue graft into a subject; And (b) administering to said subject a therapeutically effective amount of an isolated population of cells comprising an anti-third party cell that induces non-graft versus host (GVHD), having a central memory T lymphocyte (Tcm) Wherein the cell is a resistance-inducing cell and can be implanted in a lymph node after transplantation, the cell also being capable of (i) being a non-common gene in both the subject and the graft , Or (ii) the graft is a non-common gene and is a common gene to the subject.
机译:本发明提供了一种在有需要的受试者中治疗疾病的方法。该方法包括:(a)将非共有基因细胞或组织移植物植入受试者; (b)给所述受试者施用治疗有效量的分离的细胞群,所述细胞群包含抗第三方细胞,其诱导非移植物抗宿主(GVHD),具有中央记忆T淋巴细胞(Tcm),其中所述细胞是诱导抗性的细胞,并且可以在移植后植入淋巴结,该细胞还能够(i)在受试者和移植物中都是非常见基因,或者(ii)移植物是非常见基因并且是该受试者的常见基因。

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