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Oral dosage form of parathyroid hormone comprising the gastrointestinal absorption enhancer
Oral dosage form of parathyroid hormone comprising the gastrointestinal absorption enhancer
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机译:包含胃肠道吸收促进剂的甲状旁腺激素的口服剂型
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摘要
Provided is an oral administration formulation containing: a complex formed by mixing deoxycholic acid derivatives (complex of deoxycholic acid and lysine) which is a gastrointestinal permeation enhancer to parathyroid hormone (PTH) with mechanism of promoting osteogenesis or teriparatide (PTH(1-34)) which is a fraction thereof at a mole ratio of 1 : 10 by ion-ion interaction; and a gastrointestinal absorption enhancer in a particle form in which the complex is coated with an enteric material. Accordingly, an intestinal membrane permeation rate of PTH and gastrointestinal absorption are promoted so the formulation is effective in treating osteoporosis.
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