APPLICATION OF PROTEIN YB-1 AND ITS FRAGMENTS FOR THE MANUFACTURE OF DRUGS IN THE TREATMENT OF ALZHEIMER'S DISEASE

摘要

1. Use of YB-1 full-length protein which has the amino acid sequence of human SEQ ID NO: 1 or rabbit SEQ ID NO: 7 or an active fragment of the protein YB-1, which has the amino acid sequence of human SEQ ID NO: 3 or SEQ ID NO rabbit : 9, or an active protein fragment YB-1, which has the amino acid sequence of human SEQ ID NO: 5 or rabbit SEQ ID NO: 11, for the manufacture of a medicament for the treatment and / or prevention of neurodegenerative diseases with abnormal protein synthesis and death of neurons in a subject due to CNI eniya of brain β-amiloida.2. A pharmaceutical composition for the treatment and / or prevention of neurodegenerative diseases with abnormal protein synthesis and death of neurons in a subject, comprising an effective amount of YB-1 full-length protein which has the amino acid sequence of human SEQ ID NO: 1 or rabbit SEQ ID NO: 7 or an active fragment protein YB-1, which has the amino acid sequence of human SEQ ID NO: 3 or rabbit SEQ ID NO: 9 or an active fragment of YB-1 protein which has an amino acid sequence of human SEQ ID NO: 5 or rabbit SEQ ID NO: 11 and f armatsevticheski acceptable carrier selected from the group consisting of a diluent, an agent enhancing the nasal delivery of proteins, protein agent promoting membrane penetration, an agent enhancing the stability of the therapeutic agent, protein or combinations thereof.