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A method of selectively removing the O-acetyl protecting groups in the presence of O-benzoyl
A method of selectively removing the O-acetyl protecting groups in the presence of O-benzoyl
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机译:一种在O-苯甲酰基存在下选择性除去O-乙酰基保护基的方法
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摘要
FIELD: chemistry.SUBSTANCE: selectively remove O-acetyl protective groups in the presence of O-benzoil in oligosaccharides by processing the oligosaccharide derivatives with hydrazine hydrate in the organic solvent, containing methylene chloride and methanol, the reaction is carried out under the action of 30-100 molar equivalents of hydrazine hydrate with respect to oligosaccharide derivatives in the mixture of chloride methylene and methanol in the volume ratio of 1:2.EFFECT: new efficient method of selectively removing O-acetyl protecting groups in the presence of O-benzoil is proposed, that significantly expands the possibilities for efficient construction of oligosaccharide chains.2 cl, 3 ex
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机译:领域:化学物质:通过在含有二氯甲烷和甲醇的有机溶剂中用水合肼处理寡糖衍生物,在寡糖中的邻苯二酚存在下选择性除去邻乙酰基保护基相对于氯亚甲基和甲醇的混合物中的寡糖衍生物,以1:2的体积比,水合肼相对于寡糖衍生物为30-100摩尔当量。效果:一种在O-苯甲腈存在下选择性去除O-乙酰保护基的有效新方法提出,大大扩展了有效构建寡糖链的可能性。2cl,3 ex
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