DIAGNOSTIC TECHNIQUE FOR GENETIC PREDISPOSITION TO ISCHEMIC STROKE DEVELOPMENT IN PATIENTS WITH ATRIAL FIBRILLATION

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine and concerns genetic predisposition to risk of ischemic stroke developing diagnostic technique in patients with atrial fibrillation (AF). Method summary: performing analysis of hemostasis system genes: polymorphism -455GA of FBG gene, polymorphism 10976GA of FVII gene, polymorphism -5TC of GPIβα gene, polymorphism 807CT of GPIα gene. At that, assigned with 0 %, upon detecting of GG polymorphism -455GA of FBG gene, AA polymorphism 10976GA of FVII gene, TT polymorphism -5TC of GPIβα gene, CC polymorphism 807CT of GPIα gene. Assigned with 50% upon detecting of GA polymorphism -455GA of FBG gene, GA polymorphism 10976GA of FVII gene, TC polymorphism -5TC of GPIβα gene, CT polymorphism 807CT of GPIα gene. Assigned with 100 % upon detecting of AA polymorphism -455GA of FBG gene, GG polymorphism 10976GA of FVII gene, CC polymorphism -5TC of GPIβα gene, TT polymorphism 807CT of GPIα gene. Genetic risk of ischemic stroke development with AF is calculated by formula: (a+b+c+d)/n, where a is percentage corresponding to polymorphism genotype -455G A of FBG gene, b is percentage corresponding to polymorphism genotype 10976GA of FVII gene, c is percentage corresponding to polymorphism genotype -5TC of GPIβα gene, d is percentage corresponding to polymorphism genotype 807CT of GPIα gene, n is number of studied genotypes; risk is considered to be low at value from 0 to 30 %, average is from 30 to 60 %, high is from 60 % and more.;EFFECT: proposed method allows to highlight genetic risk of ischemic stroke development in presence of AF in patient and increase ischemic stroke developing individual prevention quality in given group of patients.;1 cl, 5 dwg, 5 tbl, 2 ex