METHOD OF PRODUCING COMPOSITE 3D FRAME FOR REPLACEMENT OF BONE-CARTILAGE DEFECTS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine and represents method of producing composite 3D frame for replacement of bone-cartilage defects involving preparation of fluid hydrogel containing sodium alginate and calcium phosphate excipient, application of hydrogel on platform, forming three-dimensional frame with fixed structure. Three-dimensional frame formed by 3D injection printing with application of hydrogel in layers with fixing structure on platform, stepwise cooled from -5±1 °C to -30±1 °C depending on number of applied layers, wherein temperature in printing layer is -5±1 °C. Liquid hydrogel contains, wt% in terms of dry weight of hydrogel: sodium alginate – 40–90; filler – 10–60. Three-dimensional frame has high plasticity of polymer and in combination with preset architecture and porosity makes it possible to fill bone-cartilage defects of various shape and size.;EFFECT: technical result is obtaining 3D frame by 3D injection printing.;3 cl, 6 ex, 1 tbl