SYSTEM OF INTRAVENTRICULAR DRUG DELIVERY TO IMPROVE OUTCOME AFTER BRAIN DAMAGE, VIOLATING CEREBRAL BLOOD CIRCULATION

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to medicine, namely to neurology, neurosurgery and pharmacology, and can be used for therapeutic treatment of delayed state complication, wherein blood gets into subarachnoid space. Application of microdispersed composition is proposed for preparing drug for treating such conditions. Composition contains powder suspension of microparticles, containing therapeutic amount of agent, selected from group consisting of calcium channel antagonist, endothelin antagonist (ET) and antagonist of channels with transitory receptor potential (TRP), impregnated in matrix or on matrix of biopolymer, and pharmaceutical carrier, which gives viscosity to composition. Microparticles have uniform distribution of size of microparticles. Average particle size is 66 μm. Each microparticle contain at least 40 wt% of therapeutic agent. Method of treatment is also disclosed, which involves use of said microdispersed composition. Sterile set comprises microdisperse composition and syringes with suspension and pharmaceutically acceptable carrier. Method for obtaining microdispersed composition involves use of said set.;EFFECT: use of inventions provides gradual release of therapeutic agent for long period of time and introduction into brain ventricle so, that therapeutic composition contacts and flows, at least one cerebral artery in subarachnoid space, not entering system of blood flow in amount, which causes undesirable side effects.;23 cl, 21 dwg, 6 tbl, 1 ex