COMPOSITION CONTAINING N-ACETYLCYSTEINE IN COMBINATION WITH PROBIOTIC BACTERIA ABLE TO RESTORE THEIR OWN STOMACH BARRIER EFFECT LOST PHARMA DURING PHARMACOLOGICAL TREATMENT OF GASTRIC HYPERACIDITY

摘要

FIELD: medicine, pharmacy.;SUBSTANCE: pharmaceutical composition for intestinal microflora balance restoration for subjects taking medications for reduction or treatment of gastric hyperacidity. The composition contains effective amounts of bacteria strains Lactobacillus pentosus LPS01 DSM 21980, Lactobacillus plantarum LP01 LMG P-21021, Lactobacillus rhamnosus LR06 DSM 21981 and Lactobacillus delbrueckii LDD 01 (DSMZ 20074) DSM 22106 in combination with N-acetylcysteine. Moreover, these strains are capable of colonizing the stomach at pH of from 4.0 to 5.5, and produce bacteriocins and/or metabolites, and/or hydrogen peroxide. A pharmaceutical composition cntaining effective amounts of the above bacterial strains and a drug belonging to the class of proton pump (PPI) inhibitors are also proposed. The said composition is intended to restore the intestinal microflora balance in subjects taking medications for reduction or treatment of gastric hyperacidity, dyspepsia, gastric ulcer disease and duodenal ulcer disease, gastric ulcer, gastric and duodenal ulcer, duodenal ulcer, gastritis caused by Helicobacter pylori, as well as gastroesophageal reflux disease. Food composition and food supplement with the said strains in effective amounts in combination with N-acetylcysteine are also proposed.;EFFECT: group of inventions provides ability to repair stomach own barrier effect lost during pharmacological treatment of gastric hyperacidity, and minimizes the secondary effects of such pharmacological treatment.;15 cl, 2 dwg, 6 tbl