SITE-SPECIFIC MONOPHYLATED ANALYGES OF EXCENDIN AND THE METHOD OF THEIR PRODUCTION

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to a site-specific mono-pegylated analog of the exendin, and can be used in medicine. The use of the more stable protecting group Dde (N-1-α(4,4-dimethyl-2,6-dioxo-cyclohexylene)) at the stage of synthesis of the exendin analog allows avoiding the side effects of polypegylation of the protein not prevented by unstable protecting groups.;EFFECT: invention makes it possible to achieve a high yield of a mono-pegylated analog of the exendin at a low reaction molar ratio compared to known methods for the preparation of derivatives of this kind.;11 cl, 6 dwg, 4 ex